Jeudi 24 septembre 2015 - Amphi du CNRS, 1919 route de Mende 34000 Montpelier
With increasing capacity to generate vast data at low cost for each patient, physicians will soon be able to treat patients in a way that is most appropriate for them as individuals. This is often referred to as personalized or precision medicine. For instance, genome sequencing (sequencing all of the DNA for a patient or a cancel cell), presents doctors with a complete set of genetic mutations and variations. This is already making a dramatic impact on the capacity of doctors to understand the causes of cancer or risks for cancers and to recommend appropriate treatments.
New technologies are transforming human genetics by making the full DNA sequence of individuals available at affordable prices. The challenge now lies in the creation of software to perform detailed analysis of the combinations of the 6 billion letters (A, C, G and T) that compose a human personal genome. Scientists are working to create computer programs and develop analysis methods that will allow the information to be used in precision medicine, with much of the early impact expected to relate to cancer treatment.
The purpose of this workshop is to present current efforts developed in Vancouver and Montpellier towards computational precision medicine. It will allow scientists, physicians, students and companies from both locations to come together to share knowledge, and to develop specific collaborative partnerships to accelerate this critical research.
8:30 introduction : Dr. Jacques Mercier, VP Research, University of Montpellier Dr. Francois Henn, VP International Affairs, University of Montpellier Dr. Mathieu Leporini, Science & Technology Attaché, Consulate General of France in Vancouver
9:00 – 10:30 Session 1 : Algorithms and advanced informatics for genome analysis Dr. Inanc Birol - Assembly algorithms for analysis of WGS Dr. Eric Rivals - Correction of long sequencing reads: a novel approach Dr. Thérèse Commes - Transcriptomic analyses with RNA-seq: Benchmarks, tools and applications in cancer
10:30 – 11:00 Coffee break
11:00 – 12:30 Session 2 : Genome mutation interpretation Dr. Wyeth Wasserman - Selecting causal mutations in genome sequences Dr. Jacques Colinge - Linking drug target profiles and genomes over a biological network Dr. Sohrab Shah - Inferring fitness landscapes in cancers Dr Ovidiu Radulescu - Systems biology of cancer signaling pathways: from data to mechanisms and targets
12:30 – 14:00 Lunch
14:00 – 15:30 Session 3 : Personalizing cancer therapies using DNA sequencing Dr. Steven Jones - Personalized therapy in cancer through genomic analysis Dr. Samuel Aparicio - Clonal evolution and the genomics of cancer medicine Dr. Laurent Bréhélin - Modelling gene expression in cancer personalized medicine
15:30 – 16:00 Coffee break
16:00 – 17:30 Session 4 : Rare disorders and genome sequencing Dr. Clara van Karnebeek - Applied genomics to enhance early diagnosis and treatment of intellectual developmental disabilities Dr. Andrey Kajava - Detecting predispositions to Amyloidosis by analyzing proteomes
The workshop is supported by the Consulate General of France in Vancouver, Genome British Columbia, the University of British Columbia, the Computational Biology Institute of Montpellier, the University of Montpellier and the Molecular Genetics Institute of Montpellier.